Claude Designed Protein Binders That Hit 14 of 15 Targets, Validated Blind by Two CROs at More Than Double the Usual Rate
Anthropic published wet-lab validation on August 18: Claude generated 30 candidate binders for each of 15 targets — 1,320 designs in total — and independent expression testing by Adaptyv Bio and Twist Bioscience confirmed 354 binders spanning 14 of the 15 targets. Designing against all targets simultaneously, Mythos Preview hit 26.7% and Opus 4.8 hit 22.6%; handling each target independently, Mythos Preview reached 35.1%, against what Anthropic describes as a typical 10–15% industry rate. These dual-use biology capabilities remain closed to general access in Claude Fable 5.











